BIOCREDIT Malaria Ag Pf (pLDH/HRPⅡ)

One Step Malaria Ag Pf (pLDH/HRPⅡ) Test

BIOCREDIT Malaria Ag Pf (pLDH/HRPⅡ) can detect not only HRPⅡ but also pLDH prevailing over false negative issues that have been reported due to HRPⅡ gene deletion issues since 2015. The Plasmodium Lactate Dehydrogenase (pLDH) is an oxidoreductase. It is the last enzyme of the glycolytic pathway, essential for ATP generation, and one of the most abundant enzymes expressed by P.falciparum. pLDH does not persist in the blood but clears about the same time as the parasites following successful treatment. The lack of antigen persistence after treatment makes the pLDH from P.vivax, P.ovale, or P.malariae exhibit 90-92% identity to pLDH from P.falciparum. HRPⅡ is expressed only by P.falciparum. Therefore test result will be expressed as negative (some P.falciparum strains also don’t have HRPⅡ). The variability in the results of HRPⅡ-based RDTs is related to the variability in the target antigen.

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